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Seminar on Theoretical investigation of Batch and Simulated Moving Bed Chromatographic process

  • Title: "Theoretical investigation of Batch and Simulated Moving Bed Chromatographic process"
  • Name: Ms. Fouzia ABdul Sattar
  • Date: Feb 26, 2016 (Friday)
  • Time: 14:45-15:45 hrs
  • Venue: Room # B-03, Academic Block-III (BIO Block)

Abstract: The separation and purification of mixture components is highly important in several industries, such as pharmaceutical, food, biomedical, environmental, fine chemicals, and so on. The liquid batch and simulated moving bed (SMB) chromatographic processes are theoretically investigated for separation and purification of different chemical species. Both non-reactive and reactive chromatographic processes are investigated. The SMB chromatography is a continuous purification technique that has higher throughput and requires less solvent than regular batch chromatography. Even for difficult separations, it can achieve high yield and high purity at a reasonable production rate. In the reactive non-isothermal chromatographic process a combination of chemical reaction and a controlled temperature variation can further improve the separation process. In such situations, the mathematical models become even more complicated. These transient sorption separation processes can be modelled using nonlinear convection-dominated partial differential equations (PDEs) coupled with some algebraic and/or differential equations.  The presence of nonlinear transport dominated terms in mass and energy balance equations and stiffness of the reaction terms are the main sources of instabilities for a numerical scheme. A high resolution finite volume scheme is extended to solve the model equations. The considered numerical case studies demonstrate the coupling of concentration and thermal fronts and identify the key parameters that influence the reactor performance. The numerical results also verify the accuracy of proposed numerical algorithm and quantify the relevant thermal effects.

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